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Gamma Interferon-Mediated Inflammation Is Associated with Lack of Protection from Intravaginal Simian Immunodeficiency Virus SIVmac239 Challenge in Simian-Human Immunodeficiency Virus 89.6-Immunized Rhesus Macaques

Although gamma interferon (IFN-γ) is a key mediator of antiviral defenses, it is also a mediator of inflammation. As inflammation can drive lentiviral replication, we sought to determine the relationship between IFN-γ-related host immune responses and challenge virus replication in lymphoid tissues...

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Udgivet i:J Virol
Principais autores: Abel, Kristina, La Franco-Scheuch, Lisa, Rourke, Tracy, Ma, Zhong-Min, de Silva, Veronique, Fallert, Beth, Beckett, Laurel, Reinhart, Todd A., Miller, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368742/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14694116/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.2.841-854.2004
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