Moderate-level gene amplification in methotrexate-resistant Chinese hamster ovary cells is accompanied by chromosomal translocations at or near the site of the amplified DHFR gene.
In previous studies, we have described several classes of methotrexate-resistant Chinese hamster ovary cell lines. Although the RI class is resistant because of an altered target enzyme, dihydrofolate reductase, the RIII class derived from RI cells is somewhat more resistant because of a moderate am...
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| Published in: | Mol Cell Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
1984
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC368659/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6700586/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.4.1.69-76.1984 |
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