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Mechanical Resistance in Unstructured Proteins

Single-molecule pulling experiments on unstructured proteins linked to neurodegenerative diseases have measured rupture forces comparable to those for stable folded proteins. To investigate the structural mechanisms of this unexpected force resistance, we perform pulling simulations of the amyloid β...

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Sonraí Bibleagrafaíochta
Main Authors: Jónsson, Sigurður Ægir, Mitternacht, Simon, Irbäck, Anders
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Biophysical Society 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686333/
https://ncbi.nlm.nih.gov/pubmed/23790381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.05.003
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