Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors

Androgen receptor (AR) signaling persists in castration-resistant prostate carcinomas (CRPCs), due to several mechanisms that include increased AR expression and intratumoral androgen metabolism. We investigated the mechanisms underlying aberrant expression of transcripts involved in androgen metabo...

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Detalhes bibliográficos
Main Authors: Mitsiades, Nicholas, Sung, Clifford C., Schultz, Nikolaus, Danila, Daniel C., He, Bin, Eedunuri, Vijay Kumar, Fleisher, Martin, Sander, Chris, Sawyers, Charles L., Scher, Howard I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685485/
https://ncbi.nlm.nih.gov/pubmed/22971343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1335
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