A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease

Dendritic cells (DC) migrate to lymph nodes on expression of C-C motif chemokine receptor 7 (CCR7) and control immune activity. Leptin, an immunomodulatory adipokine, functions via leptin receptors, signaling via the long isoform of receptor, LepRb. Leptin promotes DC maturation and increases CCR7 e...

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Autores principales: Al-Hassi, H O, Bernardo, D, Murugananthan, A U, Mann, E R, English, N R, Jones, A, Kamm, M A, Arebi, N, Hart, A L, Blakemore, A I F, Stagg, A J, Knight, S C
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684777/
https://ncbi.nlm.nih.gov/pubmed/23168838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2012.113
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