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Probing Residue-Specific Interactions in the Stabilization of Proteins Using High-Resolution NMR: A Study of Disulfide Bond Compensation

It is well established that the oxidation state of cysteine residues in proteins are critical to overall physical stability. The presence of disulfide bonds most often imparts thermodynamic stability, and as such, engineered disulfide bonds have become a means for improving the viability of protein...

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Hlavní autoři: Skinner, Andria L., Laurence, Jennifer S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683975/
https://ncbi.nlm.nih.gov/pubmed/20187138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22055
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