Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance

Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here, we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1.3 channel, counteracts the negative effects of increased caloric intake in mice fed a diet rich in fat and fructose. ShK-186 red...

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Detalhes bibliográficos
Main Authors: Upadhyay, Sanjeev Kumar, Eckel-Mahan, Kristin L., Mirbolooki, M. Reza, Tjong, Indra, Griffey, Stephen M., Schmunk, Galina, Koehne, Amanda, Halbout, Briac, Iadonato, Shawn, Pedersen, Brian, Borrelli, Emiliana, Wang, Ping H., Mukherjee, Jogeshwar, Sassone-Corsi, Paolo, Chandy, K. George
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683782/
https://ncbi.nlm.nih.gov/pubmed/23729813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221206110
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