Antibodies targeting dengue virus envelope domain III are not required for serotype-specific protection or prevention of enhancement in vivo

The envelope (E) protein of dengue virus (DENV) is composed of three domains (EDI, EDII, EDIII) and is the main target of neutralizing antibodies. Many monoclonal antibodies that bind EDIII strongly neutralize DENV. However in vitro studies indicate that anti-EDIII antibodies contribute little to th...

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Autori principali: Williams, Katherine L., Wahala, Wahala M.P.B., Orozco, Susana, de Silva, Aravinda M., Harris, Eva
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683589/
https://ncbi.nlm.nih.gov/pubmed/22537810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.03.003
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