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Delta and Kappa Opioid Receptor Polymorphisms Influence the Effects of Naltrexone on Subjective Responses to Alcohol
Naltrexone, one of four FDA-approved pharmacotherapies for alcohol dependence, has shown moderate efficacy in clinical trials. Pharmacogenetic effects have been reported such that allelic variation at the gene encoding the mu-opioid receptor (OPRM1, rs1799971) predicts naltrexone-induced blunting of...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3683577/ https://ncbi.nlm.nih.gov/pubmed/22954510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2012.08.019 |
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