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Can ‘Humanized’ Mice Improve Drug Development in the 21(st) Century?
Chimeric mice, which have human hepatocytes engrafted in their liver, have been used to study human drug metabolism and pharmacodynamic responses for nearly 20 years. However, there are very few examples where their use has prospectively impacted the development of a candidate medication. Here, thre...
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3682766/ https://ncbi.nlm.nih.gov/pubmed/23602782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2013.03.005 |
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