Preclinical evaluation of the abuse potential of Pitolisant, a histamine H(3) receptor inverse agonist/antagonist compared with Modafinil

BACKGROUND AND PURPOSE: Pitolisant, a histamine H(3) receptor inverse agonist/antagonist is currently under Phase III clinical trials for treatment of excessive daytime sleepiness namely in narcoleptic patients. Its drug abuse potential was investigated using in vivo models in rodents and monkeys an...

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Detalhes bibliográficos
Main Authors: Uguen, M, Perrin, D, Belliard, S, Ligneau, X, Beardsley, PM, Lecomte, JM, Schwartz, JC
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682710/
https://ncbi.nlm.nih.gov/pubmed/23472741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12149
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