A Self-compartmentalizing Hexamer Serine Protease from Pyrococcus Horikoshii: SUBSTRATE SELECTION ACHIEVED THROUGH MULTIMERIZATION

Oligopeptidases impose a size limitation on their substrates, the mechanism of which has long been under debate. Here we present the structure of a hexameric serine protease, an oligopeptidase from Pyrococcus horikoshii (PhAAP), revealing a complex, self-compartmentalized inner space, where substrat...

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Detalhes bibliográficos
Main Authors: Menyhárd, Dóra K., Kiss-Szemán, Anna, Tichy-Rács, Éva, Hornung, Balázs, Rádi, Krisztina, Szeltner, Zoltán, Domokos, Klarissza, Szamosi, Ilona, Náray-Szabó, Gábor, Polgár, László, Harmat, Veronika
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682586/
https://ncbi.nlm.nih.gov/pubmed/23632025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451534
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