Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion

Aggregation of α-synuclein can be promoted by the tubulin polymerization-promoting protein/p25α, which we have used here as a tool to study the role of autophagy in the clearance of α-synuclein. In NGF-differentiated PC12 catecholaminergic nerve cells, we show that de novo expressed p25α co-localize...

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Bibliographic Details
Main Authors: Ejlerskov, Patrick, Rasmussen, Izabela, Nielsen, Troels Tolstrup, Bergström, Ann-Louise, Tohyama, Yumi, Jensen, Poul Henning, Vilhardt, Frederik
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682534/
https://ncbi.nlm.nih.gov/pubmed/23629650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401174
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