Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury

INTRODUCTION: Acute lung injury (ALI) is a common disease in critically ill patients with a high morbidity and mortality. 12/15-lipoxygenase (12/15-LO) is an enzyme generating 12-hydroxy-eicosatetraenoic acid (12-HETE) and 15-HETE from arachidonic acid. It has been shown that 12/15-LO is involved in...

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Main Authors: Rossaint, Jan, Nadler, Jerry L, Ley, Klaus, Zarbock, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682261/
https://ncbi.nlm.nih.gov/pubmed/22973824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc11518
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