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Selenium in Thioredoxin Reductase: A Mechanistic Perspective()

Most high M(r) thioredoxin reductases (TRs) have the unusual feature of utilizing a vicinal disulfide bond (Cys(1)-Cys(2)) which form an eight-membered ring during the catalytic cycle. Many eukaryotic TRs have replaced the Cys(2) position of the dyad with the rare amino acid selenocysteine (Sec). He...

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Main Authors: Lacey, Brian M., Eckenroth, Brian E., Flemer, Stevenson, Hondal, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682215/
https://ncbi.nlm.nih.gov/pubmed/18986163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800951f
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