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Altered APP Carboxyl-Terminal Processing Under Ferrous Iron Treatment in PC12 Cells
Amyloid-β peptide (Aβ), generated by proteolytic cleavage of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). The key step in the generation of Aβ is cleavage of APP by beta-site APP-cleaving enzyme 1 (BACE1). Levels of BACE1 are increas...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Korean Physiological Society and The Korean Society of Pharmacology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3682078/ https://ncbi.nlm.nih.gov/pubmed/23776394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2013.17.3.189 |
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