Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

Trichothiodystrophy (TTD) is a rare, autosomal recessive nucleotide excision repair (NER) disorder caused by mutations in components of the dual functional NER/basal transcription factor TFIIH. TTD mice, carrying a patient-based point mutation in the Xpd gene, strikingly resemble many features of th...

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Bibliographic Details
Main Authors:	Diderich, Karin E. M., Nicolaije, Claudia, Priemel, Matthias, Waarsing, Jan H., Day, Judd S., Brandt, Renata M. C., Schilling, Arndt F., Botter, Sander M., Weinans, Harrie, van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H. J., van Leeuwen, Johannes P. T. M.
Format:	Artigo
Language:	Inglês
Published:	Springer Netherlands 2011
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3682057/ https://ncbi.nlm.nih.gov/pubmed/21814739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-011-9291-8
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Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

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