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Impact of Ribosomal Modification on the Binding of the Antibiotic Telithromycin Using a Combined Grand Canonical Monte Carlo/Molecular Dynamics Simulation Approach

Resistance to macrolide antibiotics is conferred by mutation of A2058 to G or methylation by Erm methyltransferases of the exocyclic N6 of A2058 (E. coli numbering) that forms the macrolide binding site in the 50S subunit of the ribosome. Ketolides such as telithromycin mitigate A2058G resistance ye...

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書誌詳細
主要な著者: Small, Meagan C., Lopes, Pedro, Andrade, Rodrigo B., MacKerell, Alexander D.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681621/
https://ncbi.nlm.nih.gov/pubmed/23785274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003113
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