Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway

Simalikalactone E (SkE) is a quassinoid extracted from a widely used Amazonian antimalarial remedy. Although SkE has previously been shown to have cytostatic and/or cytotoxic activities in some tumor cell lines, its mechanism of action has not yet been characterized. We show here that SkE in the hig...

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Detalhes bibliográficos
Main Authors: Robert, Guillaume, Jullian, Valérie, Jacquel, Arnaud, Ginet, Clémence, Dufies, Maeva, Torino, Stephanie, Pottier, Anaïs, Peyrade, Frederic, Tartare-Deckert, Sophie, Bourdy, Geneviève, Deharo, Eric, Auberger, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681504/
https://ncbi.nlm.nih.gov/pubmed/23518796
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