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Bacillus anthracis spores and lethal toxin induce IL-1β via functionally distinct signaling pathways
Previous reports suggested that lethal toxin (LT)-induced caspase-1 activity and/or IL-1β accounted for Bacillus anthracis (BA) infection lethality. In contrast, we now report that caspase-1-mediated IL-1β expression in response to BA spores is required for anti-BA host defenses. Caspase-1(−/−) and...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3681412/ https://ncbi.nlm.nih.gov/pubmed/18493980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838141 |
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