Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk

INTRODUCTION: Transforming growth factor beta (TGF-β) has a dual role during tumor progression, initially as a suppressor and then as a promoter. Epithelial TGF-β signaling regulates fibroblast recruitment and activation. Concurrently, TGF-β signaling in stromal fibroblasts suppresses tumorigenesis...

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Detalhes bibliográficos
Main Authors: Matise, Lauren A, Palmer, Trenis D, Ashby, William J, Nashabi, Abudi, Chytil, Anna, Aakre, Mary, Pickup, Michael W, Gorska, Agnieszka E, Zijlstra, Andries, Moses, Harold L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680921/
https://ncbi.nlm.nih.gov/pubmed/22748014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3217
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