MCC-134, a Single Pharmacophore, Opens Surface ATP–Sensitive Potassium Channels, Blocks Mitochondrial ATP–Sensitive Potassium Channels, and Suppresses Preconditioning

BACKGROUND: MCC-134 (1-[4-(H-imidazol-1-yl)benzoyl]-N-methylcyclobutane-carbothioamide), a newly developed analog of aprikalim, opens surface smooth muscle–type ATP-sensitive potassium (K(ATP)) channels but inhibits pancreatic K(ATP) channels. However, the effects of MCC-134 on cardiac surface K(ATP...

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Main Authors: Sasaki, Norihito, Murata, Mitsushige, Guo, Yiru, Jo, Su-Hyun, Ohler, Andreas, Akao, Masaharu, O’Rourke, Brian, Xiao, Rui-Ping, Bolli, Roberto, Marbán, Eduardo
Format: Artigo
Language:Inglês
Published: 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680097/
https://ncbi.nlm.nih.gov/pubmed/12615799
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