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Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock: Downstream Regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 Expression
Background. NOS/(•)NO inhibitors are potential therapeutics for sepsis, yet they increase clinical mortality. However, there has been no in vivo investigation of the (in vitro) (•)NO scavenger, cobalamin's (Cbl) endogenous effects on NOS/(•)NO/inflammatory mediators during the immune response t...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Hindawi Publishing Corporation
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3679756/ https://ncbi.nlm.nih.gov/pubmed/23781123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/741804 |
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