Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock: Downstream Regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 Expression

Background. NOS/(•)NO inhibitors are potential therapeutics for sepsis, yet they increase clinical mortality. However, there has been no in vivo investigation of the (in vitro) (•)NO scavenger, cobalamin's (Cbl) endogenous effects on NOS/(•)NO/inflammatory mediators during the immune response t...

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Detalhes bibliográficos
Main Authors: Sampaio, André L. F., Dalli, Jesmond, Brancaleone, Vincenzo, D'Acquisto, Fulvio, Perretti, Mauro, Wheatley, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679756/
https://ncbi.nlm.nih.gov/pubmed/23781123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/741804
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