Amplification of the IMP dehydrogenase gene in Chinese hamster cells resistant to mycophenolic acid.
The regulation of IMP dehydrogenase (IMPDH) was analyzed in Chinese hamster V79 cell variants that exhibit different degrees of resistance to the cytotoxic effect of mycophenolic acid, a specific inhibitor of IMPDH. Western blot (immunoblot) analysis with an IMPDH antiserum revealed a 14- to 27-fold...
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| Published in: | Mol Cell Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
1987
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC367972/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2890098/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.7.9.3328-3331.1987 |
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