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Cyclic AMP-dependent protein kinase regulates sensitivity of cells to multiple drugs.

The isolation of mutant cell lines affecting the activity of cyclic AMP (cAMP)-dependent protein kinase (PK-A) has made it possible to determine the function of this kinase in mammalian cells. We found that both a CHO cell mutant with a defective regulatory subunit (RI) for PK-A and a transfectant c...

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Detalhes bibliográficos
Main Authors: Abraham, I, Hunter, R J, Sampson, K E, Smith, S, Gottesman, M M, Mayo, J K
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC367942/
https://ncbi.nlm.nih.gov/pubmed/2823117
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