Molecular Signature of High Yield (Growth) Influenza A Virus Reassortants Prepared as Candidate Vaccine Seeds

BACKGROUND: Human influenza virus isolates generally grow poorly in embryonated chicken eggs. Hence, gene reassortment of influenza A wild type (wt) viruses is performed with a highly egg adapted donor virus, A/Puerto Rico/8/1934 (PR8), to provide the high yield reassortant (HYR) viral ‘seeds’ for v...

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Detalhes bibliográficos
Main Authors: Ramanunninair, Manojkumar, Le, Jianhua, Onodera, Shiroh, Fulvini, Andrew A., Pokorny, Barbara A., Silverman, Jeanmarie, Devis, Rene, Arroyo, Jennifer M., He, Yu, Boyne, Alex, Bera, Jayati, Halpin, Rebecca, Hine, Erin, Spiro, David J., Bucher, Doris
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679156/
https://ncbi.nlm.nih.gov/pubmed/23776579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065955
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