Low-weight polyethylenimine cross-linked 2-hydroxypopyl-β-cyclodextrin and folic acid as an efficient and nontoxic siRNA carrier for gene silencing and tumor inhibition by VEGF siRNA

BACKGROUND: Targeted delivery of small interfering RNA (siRNA) has been regarded as one of the most important technologies for the development of siRNA therapeutics. However, the need for safe and efficient delivery systems is a barrier to further development of RNA interference therapeutics. In thi...

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Hlavní autoři: Li, Jin-Ming, Wang, Yuan-Yuan, Zhang, Wei, Su, Hua, Ji, Liang-Nian, Mao, Zong-Wan
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2013
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3678862/
https://ncbi.nlm.nih.gov/pubmed/23766646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S42440
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