Cyclic Strain Anisotropy Regulates Valvular Interstitial Cell Phenotype and Tissue Remodeling in 3D Culture

Many planar connective tissues exhibit complex anisotropic matrix fiber arrangements that are critical to their biomechanical function. This organized structure is created and modified by resident fibroblasts in response to mechanical forces in their environment. The directionality of applied strain...

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Bibliographische Detailangaben
Hauptverfasser: Gould, Russell A., Chin, Karen, Santisakultarm, Thom P., Dropkin, Amanda, Richards, Jennifer M., Schaffer, Chris B., Butcher, Jonathan T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3678539/
https://ncbi.nlm.nih.gov/pubmed/22281945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2012.01.006
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