Mechanical Stress and ATP Synthesis are coupled by Mitochondrial Oxidants in Articular Cartilage

Metabolic adaptation of articular cartilage under joint loading is evident and matrix synthesis seems to be critically tied to ATP. Chondrocytes utilize the glycolytic pathway for energy requirements but seem to require mitochondrial reactive oxygen species (ROS) to sustain ATP synthesis. The role o...

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Main Authors: Wolff, Katherine J, Ramakrishnan, Prem S, Brouillette, Marc J, Journot, Brice, Mckinley, Todd O, Buckwalter, JA, Martin, James A
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3678272/
https://ncbi.nlm.nih.gov/pubmed/22930474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.22223
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