The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans

Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic HLA class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia through admixture with archaic huma...

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Autors principals: Abi-Rached, Laurent, Jobin, Matthew J, Kulkarni, Subhash, McWhinnie, Alasdair, Dalva, Klara, Gragert, Loren, Babrzadeh, Farbod, Gharizadeh, Baback, Luo, Ma, Plummer, Francis A, Kimani, Joshua, Carrington, Mary, Middleton, Derek, Rajalingam, Raja, Beksac, Meral, Marsh, Steven GE, Maiers, Martin, Guethlein, Lisbeth A, Tavoularis, Sofia, Little, Ann-Margaret, Green, Richard E, Norman, Paul J, Parham, Peter
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677943/
https://ncbi.nlm.nih.gov/pubmed/21868630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1209202
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