Fludarabine-Based Conditioning for Marrow Transplantation from Unrelated Donors in Severe Aplastic Anemia: Early Results of a Cyclophosphamide Dose Deescalation Study Show Life-Threatening Adverse Events at Predefined Cyclophosphamide Dose Levels

Excessive adverse events were encountered in a Phase I/II study of cyclophosphamide (CY) dose deescalation in a fludarabine-based conditioning regimen for bone marrow transplantation from unrelated donors in patients with severe aplastic anemia. All patients received fixed doses of antithymocyte glo...

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Detalhes bibliográficos
Main Authors: Tolar, Jakub, Deeg, H. Joachim, Arai, Sally, Horwitz, Mitchell, Antin, Joseph H., McCarty, John M., Adams, Roberta H., Ewell, Marian, Leifer, Eric S., Gersten, Iris D., Carter, Shelly L., Horowitz, Mary M., Nakamura, Ryotaro, Pulsipher, Michael A., DiFronzo, Nancy L., Confer, Dennis L., Eapen, Mary, Anderlini, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677744/
https://ncbi.nlm.nih.gov/pubmed/22546497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2012.04.014
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