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Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for targeting of CD44-positive and drug-resistant tumors

Many drug-resistant tumors and cancer stem cells (CSC) express elevated levels of CD44 receptor, a cellular glycoprotein binding hyaluronic acid (HA). Here, we report the synthesis of nanogel-drug conjugates based on membranotropic cholesteryl-HA (CHA) for efficient targeting and suppression of drug...

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Detalhes bibliográficos
Main Authors: Wei, Xin, Senanayake, Thulani H., Warren, Galya, Vinogradov, Serguei V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677708/
https://ncbi.nlm.nih.gov/pubmed/23547842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc300632w
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