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Total Synthesis and Structure-Activity Relationship Study of the Potent cAMP Signaling Agonist (-)-Alotaketal A

A detailed account of the first total synthesis of alotaketal A, a tricyclic spiroketal sesterterpenoid that potently activates the cAMP signaling pathway, is provided. The synthesis employs both intra- and intermolecular reductive allylation of esters for assembling one of the fragments and their c...

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書誌詳細
主要な著者: Huang, Jinhua, Yang, Jessica R., Zhang, Jin, Yang, Jiong
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677522/
https://ncbi.nlm.nih.gov/pubmed/23584129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob40120k
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