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Gamma interferon and 5-azacytidine cause transcriptional elevation of class I major histocompatibility complex gene expression in K562 leukemia cells in the absence of differentiation.

We studied the effects of gamma interferon (IFN-gamma) on HLA class I gene expression, differentiation, and proliferative capacity of K562 human leukemia cells. In the uninduced state, K562 cells show little or no class I gene expression but actively express the erythroid-specific gamma-globin gene...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Chen, E, Karr, R W, Frost, J P, Gonwa, T A, Ginder, G D
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1986
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC367697/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2431285/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.6.5.1698
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