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The effect of repeated intramuscular alfentanil injections on experimental pain and abuse liability indices in healthy males

OBJECTIVE: Opioid-induced hyperalgesia (OIH), increased sensitivity to noxious stimuli following repeated opioid exposures, has been demonstrated in pre-clinical studies. However, there is no accepted, prospective model of OIH following repeated opioid exposures currently available in humans. This s...

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Main Authors: Tompkins, D. Andrew, Smith, Michael T., Bigelow, George E., Moaddel, Ruin, Venkata, S.L. Vatem, Strain, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676462/
https://ncbi.nlm.nih.gov/pubmed/23446076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/AJP.0b013e3182851758
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