Cytochrome P450 3A1 Mediates 2,2′,4,4′-Tetrabromodiphenyl Ether-Induced Reduction of Spermatogenesis in Adult Rats

BACKGROUND: 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) is the dominant PBDE congener in humans, wildlife, and the environment. It has been reported to be metabolized by cytochrome P450 (CYP) enzymes. Still, the effects of BDE47 on spermatogenesis failure are attracting an increasing amount of attent...

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Detalhes bibliográficos
Main Authors: Zhang, Zhan, Zhang, Xiaoming, Sun, Zhenzhen, Dong, Huibin, Qiu, Lianglin, Gu, Jun, Zhou, Jingping, Wang, Xinru, Wang, Shou-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676375/
https://ncbi.nlm.nih.gov/pubmed/23762486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066301
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