Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

The role of skeletal muscle in nonshivering thermogenesis (NST) is not well understood. Here we show that sarcolipin (Sln), a newly identified regulator of the sarco/endoplasmic reticulum Ca(2+)-ATPase (Serca) pump(1–5), is necessary for muscle-based thermogenesis. When challenged to acute cold (4 °...

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Detalhes bibliográficos
Main Authors: Bal, Naresh C, Maurya, Santosh K, Sopariwala, Danesh H, Sahoo, Sanjaya K, Gupta, Subash C, Shaikh, Sana A, Pant, Meghna, Rowland, Leslie A, Bombardier, Eric, Goonasekera, Sanjeewa A, Tupling, A Russell, Molkentin, Jeffery D, Periasamy, Muthu
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676351/
https://ncbi.nlm.nih.gov/pubmed/22961106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2897
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