Genotype Misclassification in Genetic Association Studies of the rs1042522 TP53 (Arg72Pro) Polymorphism: A Systematic Review of Studies of Breast, Lung, Colorectal, Ovarian, and Endometrial Cancer

Preferential loss of heterozygosity at the rs1042522 locus of the tumor protein 53 gene (TP53) (Arg72Pro) is observed in several tumors. Genetic association studies in oncology often use tumor tissue rather than unaffected tissue for genotyping; in such cases, loss of heterozygosity at the TP53 locu...

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Главные авторы: Dahabreh, Issa J., Schmid, Christopher H., Lau, Joseph, Varvarigou, Vasileia, Murray, Samuel, Trikalinos, Thomas A.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2013
Предметы:
Human Genome Epidemiology (Huge) Review
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676148/
https://ncbi.nlm.nih.gov/pubmed/23729685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/aje/kws394
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