Chikungunya Virus Host Range E2 Transmembrane Deletion Mutants Induce Protective Immunity against Challenge in C57BL/6J Mice

A vaccine against Chikungunya virus (ChikV), a reemerging pathogenic arbovirus, has been made by attenuating wild-type (WT) virus via truncation of the transmembrane domain (TMD) of E2 and selecting for host range (HR) mutants. Mice are a standard model system for ChikV disease and display the same...

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Autori principali: Piper, Amanda, Ribeiro, Mariana, Smith, Katherine M., Briggs, Caitlin M., Huitt, Emerson, Nanda, Kavita, Spears, Carla J., Quiles, Michelle, Cullen, John, Thomas, Malcolm E., Brown, Dennis T., Hernandez, Raquel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676113/
https://ncbi.nlm.nih.gov/pubmed/23552427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03357-12
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