Intranasal Prophylaxis with CpG Oligodeoxynucleotide Can Protect against Yersinia pestis Infection

Immunomodulatory agents potentially represent a new class of broad-spectrum antimicrobials. Here, we demonstrate that prophylaxis with immunomodulatory cytosine-phosphate-guanidine (CpG) oligodeoxynucleotide (ODN), a toll-like receptor 9 (TLR9) agonist, confers protection against Yersinia pestis, th...

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Hlavní autoři: Hickey, Anthony J., Lin, Jr-Shiuan, Kummer, Lawrence W., Szaba, Frank M., Duso, Debra K., Tighe, Michael, Parent, Michelle A., Smiley, Stephen T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676034/
https://ncbi.nlm.nih.gov/pubmed/23545300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00316-13
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