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Characterization of Site-Specific Mutations in a Short-Chain-Length/Medium-Chain-Length Polyhydroxyalkanoate Synthase: In Vivo and In Vitro Studies of Enzymatic Activity and Substrate Specificity

Saturation point mutagenesis was carried out at position 479 in the polyhydroxyalkanoate (PHA) synthase from Chromobacterium sp. strain USM2 (PhaC(Cs)) with specificities for short-chain-length (SCL) [(R)-3-hydroxybutyrate (3HB) and (R)-3-hydroxyvalerate (3HV)] and medium-chain-length (MCL) [(R)-3-h...

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Autori principali: Chuah, Jo-Ann, Tomizawa, Satoshi, Yamada, Miwa, Tsuge, Takeharu, Doi, Yoshiharu, Sudesh, Kumar, Numata, Keiji
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675958/
https://ncbi.nlm.nih.gov/pubmed/23584780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00564-13
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