Expression of metalloprotease insulin-degrading enzyme (insulysin) in normal and malignant human tissues

BACKGROUND: Insulin-degrading enzyme (IDE, insulysin, insulinase; EC 3.4.22.11), a thiol metalloendopeptidase, is involved in intracellular degradation of insulin, thereby inhibiting its translocation and accumulation to the nucleus. Recently, protein expression of IDE has been demonstrated in the e...

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Hauptverfasser: Yfanti, Christina, Mengele, Karin, Gkazepis, Apostolos, Weirich, Gregor, Giersig, Cecylia, Kuo, Wen-Liang, Tang, Wei-Jen, Rosner, Marsha, Schmitt, Manfred
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675802/
https://ncbi.nlm.nih.gov/pubmed/18813847
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