Acquired Substrate Preference for GAB1 Protein Bestows Transforming Activity to ERBB2 Kinase Lung Cancer Mutants

Activating mutations in the αC-β4 loop of the ERBB2 kinase domain, such as ERBB2(YVMA) and ERBB2(G776VC), have been identified in human lung cancers and found to drive tumor formation. Here we observe that the docking protein GAB1 is hyper-phosphorylated in carcinomas from transgenic mice and in cel...

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Hlavní autoři: Fan, Ying-Xin, Wong, Lily, Marino, Michael P., Ou, Wu, Shen, Yi, Wu, Wen Jin, Wong, Kwok-Kin, Reiser, Jakob, Johnson, Gibbes R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675622/
https://ncbi.nlm.nih.gov/pubmed/23612964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.434217
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