Crystal Structure of Mycobacterium tuberculosis Polyketide Synthase 11 (PKS11) Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones

PKS11 is one of three type III polyketide synthases (PKSs) identified in Mycobacterium tuberculosis. Although many PKSs in M. tuberculosis have been implicated in producing complex cell wall glycolipids, the biological function of PKS11 is unknown. PKS11 has previously been proposed to synthesize al...

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Autors principals: Gokulan, Kuppan, O'Leary, Seán E., Russell, William K., Russell, David H., Lalgondar, Mallikarjun, Begley, Tadhg P., Ioerger, Thomas R., Sacchettini, James C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675584/
https://ncbi.nlm.nih.gov/pubmed/23615910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.468892
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