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Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis
Geminin, an essential factor for DNA replication, directly binds to the licensing factor Cdt1 and inhibits pre-replicative complex formation to prevent re-replication. In G1, geminin levels are controlled by the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase complex, which targets gem...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675325/ https://ncbi.nlm.nih.gov/pubmed/23695679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2859 |
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