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Gag-Pol Processing during HIV-1 Virion Maturation: A Systems Biology Approach
Proteolytic processing of Gag and Gag-Pol polyproteins by the viral protease (PR) is crucial for the production of infectious HIV-1, and inhibitors of the viral PR are an integral part of current antiretroviral therapy. The process has several layers of complexity (multiple cleavage sites and substr...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675044/ https://ncbi.nlm.nih.gov/pubmed/23754941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003103 |
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