Global DNA Hypermethylation in Down Syndrome Placenta

Down syndrome (DS), commonly caused by an extra copy of chromosome 21 (chr21), occurs in approximately one out of 700 live births. Precisely how an extra chr21 causes over 80 clinically defined phenotypes is not yet clear. Reduced representation bisulfite sequencing (RRBS) analysis at single base re...

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Hauptverfasser: Jin, Shengnan, Lee, Yew Kok, Lim, Yen Ching, Zheng, Zejun, Lin, Xueqin Michelle, Ng, Desmond P. Y., Holbrook, Joanna D., Law, Hai Yang, Kwek, Kenneth Y. C., Yeo, George S. H., Ding, Chunming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675012/
https://ncbi.nlm.nih.gov/pubmed/23754950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003515
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