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Negative Regulation of the Novel norpA(P24) Suppressor, diehard4, in the Endo-lysosomal Trafficking Underlies Photoreceptor Cell Degeneration

Rhodopsin has been used as a prototype system to investigate G protein-coupled receptor (GPCR) internalization and endocytic sorting mechanisms. Failure of rhodopsin recycling upon light activation results in various degenerative retinal diseases. Accumulation of internalized rhodopsin in late endos...

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Detalhes bibliográficos
Main Authors: Lee, Jongwoo, Song, Myungchul, Hong, Sujeong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674991/
https://ncbi.nlm.nih.gov/pubmed/23754968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003559
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