Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

Fibroblast activation protein-α (FAP) identifies stromal cells of mesenchymal origin in human cancers and chronic inflammatory lesions. In mouse models of cancer, they have been shown to be immune suppressive, but studies of their occurrence and function in normal tissues have been limited. With a t...

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Hlavní autoři: Roberts, Edward W., Deonarine, Andrew, Jones, James O., Denton, Alice E., Feig, Christine, Lyons, Scott K., Espeli, Marion, Kraman, Matthew, McKenna, Brendan, Wells, Richard J.B., Zhao, Qi, Caballero, Otavia L., Larder, Rachel, Coll, Anthony P., O’Rahilly, Stephen, Brindle, Kevin M., Teichmann, Sarah A., Tuveson, David A., Fearon, Douglas T.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674708/
https://ncbi.nlm.nih.gov/pubmed/23712428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122344
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