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Dose-Dependent Targeted Suppression of P-glycoprotein Expression and Function in Caco-2 Cells
[Image: see text] The efflux transporter P-glycoprotein (Pgp), encoded by the ABCB1 gene, decreases the bioavailability of a wide range of orally administered drugs. Drug permeability studies using the in vitro Caco-2 cell model commonly rely on small molecule modulators to estimate the contribution...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674641/ https://ncbi.nlm.nih.gov/pubmed/23611024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300668e |
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